MOYAK SARATONI RIVOJLANISH FONIDA SERTOLI HUJAYRALARDA KUZATILADIGAN MORFOFUNKSIONAL O‘ZGARISHLAR
Ключевые слова:
Moyak saratoni, Sertoli hujayralari, morfologiya, morfometriya, spermatogenezАннотация
Mazkur tadqiqot moyak saratoni rivojlanishi jarayonida Sertoli hujayralarida yuzaga keladigan morfofunksional o‘zgarishlarni o‘rganishga bag‘ishlangan. Sertoli hujayralari spermatogenez jarayonini qo‘llab-quvvatlovchi va moyakning mikromuhitini tartibga soluvchi muhim komponent hisoblanadi. Ularning tuzilishi va funksional holatidagi o‘zgarishlar erkak reproduktiv tizimining buzilishiga olib keluvchi asosiy omillardan biridir. Tadqiqot davomida moyak to‘qimalarining gistologik va morfometrik tahlili asosida Sertoli hujayralarining strukturaviy reorganizatsiyasi, yadro va sitoplazma nisbatining o‘zgarishi, hujayraaro aloqalarning buzilishi hamda sekretor faoliyatdagi siljishlar aniqlandi. Shuningdek, o‘sma jarayonining rivojlanishi bilan bog‘liq ravishda Sertoli hujayralarida degenerativ va proliferativ jarayonlarning birgalikda kechishi kuzatildi. Olingan natijalar Sertoli hujayralarining moyak saratonidagi roli faqat qo‘llab-quvvatlovchi emas, balki patogenetik jarayonlarda faol ishtirok etuvchi element ekanligini ko‘rsatadi. Tadqiqot natijalari moyak saratoni patogenezini chuqurroq tushunish va yangi diagnostik hamda terapevtik yondashuvlarni ishlab chiqishda muhim ilmiy asos bo‘lib xizmat qiladi.
Библиографические ссылки
1. Griswold M.D. The central role of Sertoli cells in spermatogenesis. Seminars in Cell & Developmental Biology, 2018.
2. Sharpe R.M. Regulation of spermatogenesis. Journal of Reproduction and Fertility, 2019.
3. Skakkebaek N.E., Rajpert-De Meyts E. Testicular dysgenesis syndrome. Human Reproduction Update, 2016.
4. O’Donnell L., Stanton P.G. Sertoli cell biology and function. Endocrine Reviews, 2017.
5. De Gendt K., Verhoeven G. Sertoli cell signaling pathways. Molecular and Cellular Endocrinology, 2019.
6. Cheng C.Y., Mruk D.D. The blood-testis barrier and its regulation. Physiological Reviews, 2012.
7. McLachlan R.I. Hormonal control of spermatogenesis. Clinical Endocrinology, 2018.
8. Walker W.H. Testosterone signaling in Sertoli cells. Biology of Reproduction, 2020.
9. Saidov M., Karimov Sh. Experimental morphology of testicular pathology. Tibbiyot axborotnomasi, 2021.
10. Nieschlag E., Behre H.M. Andrology: Male reproductive health. Springer, 2010.
