THERAPEUTIC POTENTIAL OF GINGER EXTRACT IN MITIGATING SECONDARY IMMUNODEFICIENCY AND HEMATOLOGICAL DYSFUNCTIONS IN A MURINE MODEL OF ACUTE TOXIC HEPATITIS
Abstrak
Environmental xenobiotics and various disruptive factors frequently compromise immune system integrity, leading to secondary immunodeficiencies and hematological abnormalities. Plant-based immunomodulators are increasingly recognized for their low toxicity and multifaceted therapeutic potential. This study investigates the immunomodulatory and hematopoietic corrective properties of ginger extract in vivo.
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Havolalar
1. Balykova, L.A., Gerasimova, N.G., Dzyubich, L.I., et al. (2010). Immunorehabilitation of children frequently ill with respiratory infections. Practical Medicine, 45, 137-140.
2. Borshchuk, E.L., Popov, Yu.N., Sankov, A.N. (2016). Analysis of immunomodulators in the pharmaceutical market. Bulletin of Orenburg State Agrarian University, 3(59), 218-221.
3. Bulovskaya, L.N., Borisenko, G.N., Drobachenko, O.A. (1990). Determination of N-acetyltransferase activity phenotype. Leningrad, 10, 28-31.
4. Gadzhieva, T.A., Kudaev, M.T., Makhmudova, E.R., et al. (2018). Environmental risk factors and their impact on bronchial asthma morbidity in Dagestan. Journal of New Medical Technologies. Electronic edition, 12(1), 87-93.
5. Goldobin, D.D., Loktionov, A.L., Bystrova, N.A., et al. (2017). Immune disorders at systemic and local levels in chronic periodontitis, correlation with oxidative changes. Immunology, 38(1), 35-39.
6. Zakharova, D.A., Balukhto, D.A., Budina, D.V., et al. (2018). Clinical and immunological features of secondary immune insufficiency in people of different ages. Smolensk Medical Almanac, 1, 118-120.
7. Ismailov, I.Z., Zurdinov, A.Z., Sabirova, T.S. (2017). Development and application of immunomodulators at the present stage: problems and prospects. Scientific Journal, 1(14), 83-87.
8. Konoplya, A.I., Shatokhin, M.N., Mavrin, M.Yu., et al. (2017). Interrelation of immune and oxidative disorders in acute non-obstructive and obstructive pyelonephritis. Clinical Medicine, 95(4), 362-368.
9. Mirkhaidarov, A.M., Farkhutdinov, U.R., Farkhutdinov, R.R. (2016). Immune status of patients with community-acquired pneumonia and the effectiveness of immunovenin in complex therapy. Medical Bulletin of Bashkortostan, 11(2), 12-15.
10. Petrov, E.V., Aseeva, T.A., Chekhirova, G.V. (2009). Theoretical prerequisites for the development of formulations of multicomponent phytopreparations based on the experience of traditional medicine. Acta Biomedica Scientifica, 3, 222-224.
11. Ryabkova, V.A., Churilov, L.P., Schoenfeld, Y. (2020). Hyperstimulation of the immune system as a cause of autoimmune diseases. Annals of the Russian Academy of Medical Sciences, 75(3), 204-213.
12. Sambukova, T.V., Ovchinnikov, B.V., Ganapolsky, V.P., et al. (2017). Prospects for the use of phytopreparations in modern pharmacology. Reviews on Clinical Pharmacology and Drug Therapy, 15(2), 55-62.
13. Troshina, E.A. (2020). Immunoendocrinology - issues and challenges of today. Problems of Endocrinology, 66(4), 4-8.
14. Bogatov, V.V., Baklanov, P.Ya., Lozovskaya, S.A., et al. (2021). Climate change and health in the Russian Far East. Bulletin of the Far Eastern Branch of the Russian Academy of Sciences, 1(215), 5-21.
15. Bychkova, N.G., Bychkov, O.A. (2017). Immune and cytokine related disorders, aortic stiffness index in patients with arterial hypertension combined to gout. Eastern European Scientific Journal, 8-1(24), 15-19.
16. Fatimawali, F., Kalalo, M., Broolin, S., et al. (2022). Immunomodulatory potential of bioactive compounds of betel leaf extract targeting COVID-19 immunological human host proteins: An in silico study. Journal of Applied Pharmaceutical Science.
17. Jantan, I., Ahmad, W., Bukhari, S.N.A. (2015). Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Frontiers in Plant Science, 6, 1-18.
18. Jerne, N.K., Nordin, A.A. (1963). Plaque formation in agar by single antibody-producing cells. Science, 140, 405-407.
19. Khanna, K., Kohli, S.K., Kaur, R., et al. (2020). Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle. Phytomedicine, 85, 153361.
20. Kibatayev, K.M., Sakhanova, S.K., Urgushbayeva, G.M., et al. (2018). The review of actual ecological situation in Aktobe region. West Kazakhstan Medical Journal, 4(60), 18-22.
21. Kurolap, S.A., Klepikov, O.V., Vinogradov, P.M., et al. (2016). Regional geographic information systems of health and environmental monitoring. Baltic Region, 8(4), 108-124.
22. Mahima, Ingle, A.M., Verma, A.K., et al. (2013). Immunomodulators in day to day life: a review. Pakistan Journal of Biological Sciences, 16(17), 826-843.
23. Marciani, D.J. (2017). Effects of immunomodulators on the response induced by vaccines against autoimmune diseases. Autoimmunity, 50(7), 393-402.
24. Munafò, A., Burgaletto, C., Benedetto, D., et al. (2020). Repositioning of Immunomodulators: A Ray of Hope for Alzheimer’s Disease? Frontiers in Neuroscience, 4(14), 614-643.
25. Robinson, M.M., Zhang, X. (2011). The World Medicines Situation 2011. Traditional Medicines: Global Situation, Issues and Challenges, 3, 14.
26. Rölle, A., Brodin, P. (2016). Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMV. Trends in Immunology, 37(3), 233-243.
27. Sengupta, S., Bhattacharyya, D., Kasle, G., et al. (2021). Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-Coronaviruses. Frontiers in Cellular and Infection Microbiology, 11, 729622.
28. Sicherer, S.H., Sampson, H.A. (2014). Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. The Journal of Allergy and Clinical Immunology, 133(2), 291-307.
29. Wainwright, C.L., Teixeira, M.M., Adelson, D.L., et al. (2022). Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review. Pharmacological Research, 177, 106.
30. Walaa, N.A. (2017). Immunomodulatory and Natural Immunomodulators. J Allergy and Inflammation, 1(2), 1-4.
