EPIDEMIOLOGICAL PATTERNS OF HUMAN PAPILLOMAVIRUS INFECTION IN TASHKENT

Lyubov Akhmedova; Nargiz Ibadullaeva; Shakhnoza Akhmedova; Zarina Kocharova; Maya Izimbetova

Mualliflar

Lyubov Akhmedova PhD, Head of the Department of Papillomaviruses and Other Oncovirus Infections. Research Institute of Virology, Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan ##default.groups.name.author##
Nargiz Ibadullaeva MD, PhD, Scientific Secretary, Research Institute of Virology, Republican Specialized Scientific and Practical Medical Center of Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan ##default.groups.name.author##
Shakhnoza Akhmedova PhD, Researcher, Research Institute of Virology, Republican Specialized Scientific and Practical Medical Center for Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan ##default.groups.name.author##
Zarina Kocharova Virologist, Junior Researcher. Research Institute of Virology, Republican Specialized Scientific and Practical Medical Center for Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan ##default.groups.name.author##
Maya Izimbetova Laboratory assistant, junior researcher. Research Institute of Virology, Republican Specialized Scientific and Practical Medical Center for Epidemiology, Microbiology, Infectious and Parasitic Diseases, Tashkent, Uzbekistan ##default.groups.name.author##

Kalit so‘zlar:

human papillomavirus, HPV infection, epidemiology, high-risk HPV genotypes, risk factors

Abstrak

Persistent infection with human papillomavirus (HPV) is a well-established risk factor for the development of malinant epithelial tumors. Despite extensive research in women, the role of men in HPV transmission remains insufficiently studied. To investigate epidemiological patterns, genotype distribution, and risk factors associated with HPV infection in Tashkent.

A total of 183 couples were examined in Tashkent. Urethral and cervical samples (n=366) were analyzed using polymerase chain reaction (PCR) for 14 high-risk HPV genotypes. Viral load was quantified and categorized as low, moderate, or high. Epidemiological data were obtained through structured interviews.

HPV DNA was detected in 56.3% of participants and in 57.4% of couples. Concordant infection between partners was observed in 85.9% of cases. Men with urogenital symptoms demonstrated a significantly higher infection rate (83.5%) compared to asymptomatic men (18.9%) (p<0.001). Genotypes 16 and 18 were predominant. Multiple infections (2–4 genotypes) were frequently observed. Viral load was higher in women, while genotype diversity showed a strong positive correlation with the number of sexual partners in men (r=0.79).

The study demonstrates a high prevalence of HPV infection, significant genotype diversity, and substantial viral load in the population of Tashkent. Men play a key role in HPV transmission, highlighting their importance in prevention strategies

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