MENINGOKOKK INFEKSIYASINING ETIOPATOGENEZIGA ZAMONAVIY QARASHLAR

Siroj Sadullayev; Matkarim Matkarimov; Umirzoq Ikramov

Mualliflar

Siroj Sadullayev Urganch davlat tibbiyot instituti Yuqumli kasalliklar, epidemiologiya va ftiziatriya kafedrasi assistenti, Urganch, O‘zbekiston ##default.groups.name.author##
Matkarim Matkarimov Urganch davlat tibbiyot instituti 2-Davolash fakulteti Davolash ishi yo‘nalishi 2-kurs talabasi, Urganch, O‘zbekiston ##default.groups.name.author##
Umirzoq Ikramov Toshkent davlat tibbiyot universiteti Yuqumli va bolalar yuqumli kasalliklari kafedrasi assistenti, Toshkent shahar 1-sonli yuqumli kasalliklar shifoxonasi shifokori, Toshkent, O‘zbekiston ##default.groups.name.author##

Kalit so‘zlar:

meningokokk infeksiyasi, Neisseria meningitidis, etiopatogenez, virulentlik omillari, lipooligosaxarid

Abstrak

Meningokokk infeksiyasi — Neisseria meningitidis qo'zg'atuvchisi tomonidan chaqiriladigan, butun dunyo bo'ylab og'ir epidemiologik muammolardan birini tashkil etuvchi bakterial kasallik bo'lib, bolalar va o'smirlar orasida o'lim hamda nogironlik darajasi yuqori bo'lishi bilan xarakterlanadi. Ushbu ko'rib chiqish maqolasining maqsadi — meningokokk infeksiyasining etiologiyasi, virulentlik omillari, patogenezi, immunologik mexanizmlari va kasallikning og'ir kechishiga ta'sir qiluvchi zamonaviy omillarni tahlil qilishdan iborat. Maqolada Neisseria meningitidis ning mikrobiologik xususiyatlari, polisaxarid kapsula, lipooligosaxarid, pili, tashqi membrana oqsillari kabi virulentlik omillarining patogenetik ahamiyati, nazofaringeal kolonizatsiyadan tortib gematoensefalik to'siqning buzilishigacha bo'lgan bosqichlar, sitokin bo'roni va komplement tizimining roli, shuningdek mezbon genetik polimorfizmlarining kasallik kechishiga ta'siri batafsil yoritilgan. Zamonaviy genomika va proteomika tadqiqotlari, molekulyar diagnostika usullari, yangi avlod vaksinalarining samaradorligi va antibiotiklarga chidamlilik muammolari ham muhokama qilingan. Maqolada keltirilgan ma'lumotlar meningokokk infeksiyasini erta diagnostika qilish, prognozlash va patogenetik davolash taktikasini ishlab chiqishda muhim ahamiyatga ega.

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