NATRIY-GLYUKOZA KOTRANSPORTERI-2 INGIBITORLARINING 2-TIP QANDLI DIABET, YURAK YETISHMOVCHILIGI VA SURUNKALI BUYRAK KASALLIGIDA FARMAKOLOGIK SAMARADORLIGI VA XAVFSIZLIGI: REAL KLINIK MA'LUMOTLAR, SUN'IY INTELLEKT VA INDIVIDUAL DAVOLASH ASOSIDAGI TAHLIL
Kalit so‘zlar:
natriy-glyukoza kotransporteri-2 ingibitorlari, SGLT2 ingibitorlari, empagliflozin, dapagliflozin, kanagliflozinAbstrak
Dolzarblik. 2-tip qandli diabet, yurak yetishmovchiligi va surunkali buyrak kasalligi zamonaviy tibbiyotda o'zaro bog'liq, yuqori o'lim, nogironlik, gospitalizatsiya va iqtisodiy yuk bilan kechuvchi kardiorenal-metabolik kasalliklar zanjirining asosiy klinik ko'rinishlari hisoblanadi. So'nggi yillarda natriy-glyukoza kotransporteri-2 ingibitorlari (SGLT2 ingibitorlari) glyukozani kamaytiruvchi oddiy dori vositalari doirasidan chiqib, yurak va buyrakni himoya qiluvchi farmakologik guruh sifatida qayta baholandi. Maqsad. Ushbu maqolaning maqsadi SGLT2 ingibitorlarining farmakodinamik, farmakokinetik, klinik samaradorlik, xavfsizlik va real klinik amaliyotdagi qo'llanish xususiyatlarini tahlil qilish, shuningdek, real klinik ma'lumotlar (RWD), real klinik dalillar (RWE), sun'iy intellekt (SI) va individual davolash yondashuvlarining ushbu guruh dorilarni tanlashdagi ahamiyatini baholashdan iborat. Materiallar va usullar. Maqola strukturaviy adabiyotlar tahlili, retrospektiv kohort tadqiqot modeli, RWD asosidagi farmakoepidemiologik baholash va SI yordamida xavf stratifikatsiyasi metodologiyasi asosida tayyorlandi. Natijalar. Randomizatsiyalangan klinik tadqiqotlar, meta-tahlillar va real amaliyot kuzatuvlari SGLT2 ingibitorlari yurak yetishmovchiligi bo'yicha gospitalizatsiya, buyrak funksiyasining pasayishi, albuminuriya va kardiorenal kompozit natijalar xavfini kamaytirishini ko'rsatadi. Xulosa. SGLT2 ingibitorlari zamonaviy farmakologiyada kardiorenal-metabolik kasalliklarni davolash paradigmasini o'zgartirgan dori guruhi hisoblanadi. Ularni klinik amaliyotda qo'llash dalillarga asoslangan, bemor xavf profili, buyrak funksiyasi, nojo'ya ta'sir ehtimoli va davolanishga rioya qilish darajasini hisobga olgan holda amalga oshirilishi kerak.
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