РОЛЬ ХРОНИЧЕСКОЙ ГЕРПЕТИЧЕСКОЙ ИНФЕКЦИИ В ФОРМИРОВАНИИ ЗАДЕРЖКИ ПСИХОРЕЧЕВОГО РАЗВИТИЯ У ДЕТЕЙ (ОБЗОР ЛИТЕРАТУРЫ)

Зуфар Адамбаев; Мухаммаддиер Каримбердиев

Mualliflar

Зуфар Адамбаев Д.м.н., профессор, Ургенчский Государственный Медицинский Институт ##default.groups.name.author##
Мухаммаддиер Каримбердиев Клинический ординатор Ташкентского государственного медицинского университета ##default.groups.name.author##

Kalit so‘zlar:

задержка психоречевого развития, герпетическая инфекция, цитомегаловирус, вирус простого герпеса, вирус Эпштейна-Барр, нейровоспаление

Abstrak

В статье представлен обзор современных данных о влиянии хронической герпетической инфекции на психоречевое развитие детей раннего и дошкольного возраста. Рассмотрены патогенетические механизмы воздействия нейротропных вирусов семейства Herpesviridae (ЦМВ, ВПГ-1, ВПГ-2, ВЭБ, ВГЧ-6, 7, 8) на формирующийся мозг. Анализируются данные эпидемиологических исследований о корреляции между персистенцией вирусов и задержкой речевого развития (ЗПРР), когнитивными дефицитами и моторными нарушениями. Особое внимание уделено роли врожденной цитомегаловирусной инфекции и хронического воспаления, вызванного реактивацией вирусов простого герпеса и вируса Эпштейна-Барр. Обсуждаются современные методы лабораторной верификации и перспективы комплексного лечения с включением противовирусных препаратов и нейрометаболических средств

##plugins.themes.default.displayStats.downloads##

##plugins.themes.default.displayStats.noStats##

Havolalar

1. Adambaev Z.I., Kilichev I.A., Nurzhonov A.B. Khudoyberganov N.Yu., Niyazmetov M.R. Efficiency of comprehensive rehabilitation of chronic fatigue syndrome due to coronavirus infections COVID-19 // International Scientific conference "Ecological and Biological Well-Being of Flora and Fauna" (Blagoveshchensk, Amur region, Russia, May 22 - 25, 2023), BIO Web of conferences 65, 05039 (2023) EBWFF 2023.- P.1-7.

2. Bartlett AW, Hamilton ST, Shand AW, Rawlinson WD. Fetal therapies for cytomegalovirus: what we tell prospective parents. Prenat Diagn. 2020;40(13):1681–1692.

3. Chebib E, Aouameur D, Bouvrais A, et al. Predictors of cochleovestibular dysfunction in children with congenital cytomegalovirus infection. Eur J Pediatr. 2022;181(8):2909–2918.

4. Corazzi V, Sorrentino M, Paternò V, et al. Outcome of cochlear implantation in children with congenital cytomegalovirus infection: a retrospective case control study. Int J Pediatr Otorhinolaryngol. 2020;138:110364.

5. David AP, Chan DK. Management of Congenital Cytomegalovirus-Related Hearing Loss. Curr Otorhinolaryngol Rep. 2020;8(3):243–249.

6. De Cuyper E, Van Herpe E, Mulders J, et al. Risk factors for natural hearing evolution in newborns with congenital cytomegalovirus infection. JAMA Otolaryngol Head Neck Surg. 2024;150(1):30–38.

7. Diaz-Decaro J, Myers E, Mucha J, et al. A systematic literature review on the humanistic burden of cytomegalovirus. Curr Med Res Opin. 2023;39(5):739–750.

8. Dobbie AM. Evaluation and management of cytomegalovirus-associated congenital hearing loss. Curr Opin Otolaryngol Head Neck Surg. 2017;25(5):390–395

9. Engman ML, Linderholm M, Larsson H, et al. Prenatal acquired cytomegalovirus infection should be considered in children with autism. Acta Paediatr. 2015;104(9):792–795.

10. Fletcher KT, Wolf Horrell EM, Ayugi J, et al. The Natural History and Rehabilitative Outcomes of Hearing Loss in Congenital Cytomegalovirus: A Systematic Review. Otol Neurotol. 2018;39(7):854–864.

11. Fourgeaud J, Foussier F, Barbe G, et al. Predictors of the outcome at 2 years in neonates with congenital cytomegalovirus infection. Pediatrics. 2024;153(6):e2023063531.

12. Gale SD, Farrer TJ, Erbstoesser R, MacLean S, Hedges DW. Human Cytomegalovirus Infection and Neurocognitive and Neuropsychiatric Health. Pathogens. 2024 May 16;13(5):417. doi: 10.3390/pathogens13050417.

13. Gale SD, Hedges DW. Effects of Infectious Diseases on Child and Brain Development and Their Association with Poverty. In: Hedges DW, Gale SD, Erickson LD, eds. Infectious Diseases in Neurocognitive and Neuropsychiatric Medicine. Oxford; 2024.

14. Garofoli F, Calevo M, Ricci G, et al. An Italian prospective experience on the association between congenital cytomegalovirus infection and autistic spectrum disorder. J Autism Dev Disord. 2017;47(5):1490–1495.

15. Giannattasio A, Foulon I, Leruez-Ville M, et al. Neuroimaging Profiles and Neurodevelopmental Outcome in Infants with Congenital Cytomegalovirus Infection. Pediatr Infect Dis J. 2018;37(11):1028–1033.

16. Gopalakrishnan A, Thangavel S, Chowdhary S, Alexander A. Cochlear implantation in a profoundly deaf child with cystic leukoencephalopathy without megalencephaly. J Laryngol Otol. 2022;137(5):584–587.

17. Han JJ, Bae YJ, Song SK, et al. Prediction of the Outcome of Cochlear Implantation in the Patients with Congenital Cytomegalovirus Infection based on Magnetic Resonance Imaging Characteristics. J Clin Med. 2019;8(2):136.

18. Hoey AW, Pai I, Driver S, et al. Management and outcomes of cochlear implantation in patients with congenital cytomegalovirus (cCMV)-related deafness. Cochlear Implant Int. 2017;18(4):216–225.

19. Jenks CM, Hoff SR, Mithal LB. Congenital Cytomegalovirus Infection: Epidemiology, Timely Diagnosis, and Management. NeoReviews. 2021;22(9):e606–e613.

20. Jenks CM, Mithal LB, Hoff SR. Early Identification and Management of Congenital Cytomegalovirus. Otolaryngol Clin N Am. 2021;54(6):1117–1127.

21. Keymeulen A, De Meulemeester F, Lerut E, et al. Neurodevelopmental outcome in children with congenital cytomegalovirus infection: a prospective multicenter cohort study. Ear Hum Dev. 2023;182:105777.

22. Kim Y, Choi BY. Precision Medicine Approach to Cochlear Implantation. Clin Exp Otorhinolaryngol. 2022;15(4):299–309.

23. Kokkola E, Wiela-Hippius M, Kääriäinen M, et al. Long-term outcome of vestibular function and hearing in children with congenital cytomegalovirus infection: a prospective cohort study. Eur Arch Otorhinolaryngol. 2023;280(8):3141–3147.

24. Korndewal MJ, van Loon J, van der Ploeg E, et al. Long-Term impairment attributable to congenital cytomegalovirus infection: a retrospective cohort study. Dev Med Child Neurol. 2017;59(11):1261–1268.

25. Kraaijenga VJC, Van Houwelingen F, Van der Horst SF, et al. Cochlear implant performance in children deafened by congenital cytomegalovirus—A systematic review. Clin Otolaryngol. 2018;43(5):1283–1295.

26. Lanzieri TM, Boppana SB, Fowler KB, et al. Long-term outcomes of children with symptomatic congenital cytomegalovirus disease. J Perinatol. 2017;37(5):875–880.

27. Lanzieri TM, Kimberlin DW, Schleiss MR, et al. Parental perspectives on communication from health care providers following a newborn diagnosis of congenital cytomeгалovirus infection: a secondary analysis of a qualitative study. Int J Neonat Scr. 2023;9:49.

28. Lee ER, Chan DK. Implications of dried blood spot testing for congenital CMV on management of children with hearing loss: A preliminary report. Int J Pediatr Otorhinolaryngol. 2019;119:10–14.

29. Liao EN, Stephans J, Taketa E, et al. Factors associated with congenital cytomegalovirus infection detected by dried blood spot testing in children with hearing loss. Int J Pediatr Otorhinolaryngol. 2023;165:111446.

30. Lyutenski S, Götz F, Giourgas A, et al. Does severity of cerebral MRI lesions in congenital CMV infection correlates with the outcome of cochlear implantation?. Eur Arch Otorhinolaryngol. 2016;274(3):1397–1403.

31. Ogawa H. Effects of Cytomegalovirus Infection on Hearing. Pract Oto-Rhino-Laryngologica. 2024;117(9):777–784.

32. Pesch MH, Bartlett AW, Lauer CS, et al. Autism spectrum disorder diagnoses and congenital cytomegalovirus. Pediatrics. 2024;153(6):e2023064081.

33. Pesch MH, Lauer CS, Weinberg JB. Neurodevelopmental outcomes of children with congenital cytomegalovirus: a systematic scoping review. Pediatr Res. 2024;92(2):418–435.

34. Pinninti S, Hagemann TM, Stoeckel AJ, et al. Vestibular, gaze, and balance disorders in asymptomatic congenital cytomegalovirus infection. Pediatrics. 2021;147(5):e20193945.

35. Pollick SA, Noorulla F, Harrison GD, et al. Neonatal characteristics and neurodevelopmental phenotypes in congenital cytomegalovirus. Pediatr Res. 2025. https://doi.org/10.1038/s41390-025-04327-z

36. Rawlinson WD, Boppana SB, Fowler KB, et al. Congenital cytomegalovirus infection in pregnancy and the neonate: consensus recommendations for prevention, diagnosis, and therapy. Lancet Infect Dis. 2017;17(2):e177–e188.

37. Rohren L, Wacker HP, Nowak H, et al. Congenital cytomegalovirus-associated sensorineural hearing loss in children: identification following universal newborn hearing screening, effect of antiviral treatment, and long-term hearing outcomes. Ear Hear. 2024;45(3):198–206.

38. Schleiss MR, Marsh KJ. Viral Infections of the Fetus and Newborn. In: Avery's Diseases of the Newborn. Elsevier; 2018. p. 482–526.e19.

39. Teissier N, Bernard S, Quesnel S, Van Den Abbeele T. Audiovestibular consequences of congenital cytomegalovirus infection. Eur Ann Otorhinolaryngol Head Neck Dis. 2016;133(6):413–418.

40. Teissier N. Atteintes neurosensorielles de l’infection congénitale à cytomégalovirus. Bull Acad Natl Med. 2020;204(2):151–158.

41. Turriziani Colonna A, Lombardi A, Donati C, et al. Long-term clinical, audiological, visual, neurocognitive and behavioral outcome in children with symptomatic and asymptomatic congenital cytomegalovirus infection treated with valganciclovir. Front Med. 2020;7:268.

42. Vandrevala T, Opoka-Smith L, McMullan J, et al. Parenting a child with congenital cytomegalovirus infection: a qualitative study. BMJ Paediatr Open. 2020;4:e000844.

43. Wang S, Wang Y, Li Y, et al. Cochlear implantation in children with white matter lesions. Medicine. 2021;100(1):e23355.

44. Yoshida H, Takahashi H, Kanda Y, Kitaoka K, Hara M. Long-term Outcomes of Cochlear Implantation in Children With Congenital Cytomegalovirus Infection. Otol Neurotol. 2017;38(7):e190–e194.

45. Young NM, Weil C, Thomas D, Tournis E. Cochlear Implant for Children with Additional Disabilities. In: Pediatric Cochlear Implantation. Springer; 2024. p. 335–352.

46. Young NM, Weil C, Tournis E. Redefining Cochlear Implant Benefits to Appropriately Include Children with Additional Disabilities. In: Pediatric Cochlear Implantation. Springer; 2016. p. 213–226.