ENDOMETRIY SARATONIDA LIMFA TUGUNLARI METASTAZLARINI PROGNOZLASH MEZONLARI
Kalit so‘zlar:
endometriy saratoni, limfa tuguni metastazi, miometriy invaziyasi, LVSI, CA-125Abstrak
Endometriy saratonida limfa tugunlari metastazi kasallik bosqichi, adjuvant davolash hajmi va uzoq muddatli prognozni belgilovchi muhim omillardan biridir. Ushbu maqolaning maqsadi limfogen metastazlarni oldindan baholashda klinik, morfologik, instrumental va laborator mezonlarning diagnostik qiymatini tizimli tahlil qilishdan iborat. Tadqiqot 2014–2026-yillarda e’lon qilingan mahalliy va xorijiy manbalarni strukturaviy tahlil qilish asosida bajarildi; 15 ta asosiy manba tanlab olindi, shundan 8 tasi O‘zbekiston mualliflari va mahalliy ilmiy bazaga tegishli. Natijalar miometriyga chuqur invaziya (≥50%), limfovaskulyar invaziya (LVSI), yuqori darajali yoki agressiv gistologik tip, bachadon bo‘yni stromasiga o‘tish, CA-125 darajasining oshishi va tasviriy tekshiruvda shubhali limfa tugunlari metastaz xavfini eng barqaror belgilovchi mezonlar ekanini ko‘rsatdi. Zamonaviy yondashuv bitta ko‘rsatkichga emas, klinik-patologik, biomarker va radiologik belgilar kombinatsiyasiga asoslangan integrallashgan stratifikatsiyani talab qiladi. Sentinel limfa tuguni xaritalash va molekulyar tasnif bilan uyg‘un yondashuv ortiqcha limfadenektomiyani kamaytirish va yuqori xavfli bemorlarni aniqroq ajratishga xizmat qiladi
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