MODERN TREATMENT METHODS FOR SJOGREN’S SYNDROME
Ключевые слова:
Sjögren’s syndrome, autoimmune disease, xerostomia, xerophthalmia, immunomodulatory therapyАннотация
Sjögren’s syndrome is a chronic systemic autoimmune disease primarily affecting the lacrimal and salivary glands and characterized by ocular and oral dryness. The disease may also present with fatigue, arthralgia, and various extraglandular manifestations. This article examines the clinical characteristics of Sjögren’s syndrome and modern approaches to its treatment, including symptomatic, systemic, and targeted therapeutic strategies. An individualized approach based on disease severity and clinical manifestations is important for improving treatment outcomes and patients’ quality of life.
##plugins.themes.default.displayStats.downloads##
Библиографические ссылки
1. Baldini C., Fulvio G., La Rocca G. et al. Update on the pathophysiology and treatment of primary Sjögren syndrome // Nature Reviews Rheumatology. – 2024. – Vol. 20. – P. 473–491.
2. Ramos-Casals M., Brito-Zerón P., Bombardieri S. et al. EULAR recommendations for the management of Sjögren’s syndrome with topical and systemic therapies // Annals of the Rheumatic Diseases. – 2020. – Vol. 79, No. 1. – P. 3–18.
3. Shiboski C.H., Shiboski S.C., Seror R. et al. 2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren’s syndrome // Arthritis & Rheumatology. – 2017. – Vol. 69, No. 1. – P. 35–45.
4. Thorlacius G.E., Björk A., Wahren-Herlenius M. Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies // Nature Reviews Rheumatology. – 2023. – Vol. 19. – P. 288–306.
5. Nocturne G., Mariette X. B cells in the pathogenesis of primary Sjögren syndrome // Nature Reviews Rheumatology. – 2018. – Vol. 14. – P. 133–145.
6. Voulgarelis M., Tzioufas A.G. Pathogenetic mechanisms in the initiation and perpetuation of Sjögren’s syndrome // Nature Reviews Rheumatology. – 2010. – Vol. 6. – P. 529–537.
7. Shiboski C.H., Baer A.N., Shiboski S.C. et al. Natural history and clinical manifestations of primary Sjögren’s syndrome // Rheumatology. – 2021. – Vol. 60. – P. 1–12.
8. Mariette X., Criswell L.A. Primary Sjögren’s syndrome // New England Journal of Medicine. – 2018. – Vol. 378. – P. 931–939.



















