QIZAMIQDAN KEYINGI SUBAKUT SKLEROZLOVCHI PANENSEFALIT: KLINIK-NEVROLOGIK BELGILAR VA MRT-DINAMIKASINING UZOQ MUDDATLI KUZATUVI
Ключевые слова:
subakut sklerozlovchi panensefalit, qizamiq, qizamiq virusi, neyrodegenerativ kasallik, progressiv ensefalopatiyaАннотация
Subakut sklerozlovchi panensefalit (SSPE) — qizamiq virusining markaziy asab tizimida uzoq vaqt saqlanib qolishi bilan bog‘liq bo‘lgan, kam uchraydigan, ammo og‘ir kechuvchi progressiv neyrodegenerativ kasallikdir. Kasallikning klinik belgilari qizamiq infeksiyasidan bir necha yil o‘tgach namoyon bo‘lishi mumkin. Mazkur maqolada erta bolalik davrida qizamiq bilan kasallangan bemorda keyinchalik rivojlangan progressiv nevrologik buzilishlarning klinik kechishi va neyroimaging dinamikasi tahlil qilindi. Klinik kuzatuv davomida dastlab yiqilishlar, nutqning buzilishi va takroriy mushak tortishishlari kuzatilgan, keyinchalik tutqanoq xurujlari, yutish funksiyasining buzilishi, ong darajasining pasayishi hamda og‘ir motor defitsit shakllangan. Elektroensefalografik tekshiruvlarda patologik o‘zgarishlar aniqlangan. Magnit-rezonans tomografiya tekshiruvlarining dinamik tahlili dastlabki davrda oq moddadagi o‘choqli o‘zgarishlardan keyinchalik bosh miya po‘stlog‘i va miyacha atrofiyasining rivojlanishi hamda kuchayishini ko‘rsatgan. Klinik-nevrologik belgilar va MRTdagi progressiv o‘zgarishlar qizamiqdan keyingi SSPE ehtimolini ko‘rsatadi. Ushbu klinik holat qizamiq infeksiyasini, ayniqsa erta yoshdagi kasallanishni, uzoq muddatli nevrologik asoratlar nuqtayi nazaridan baholash va progressiv nevrologik simptomlar paydo bo‘lgan bemorlarda SSPEni differensial diagnostikada hisobga olish zarurligini ko‘rsatadi.
##plugins.themes.default.displayStats.downloads##
Библиографические ссылки
1. Garg R.K., Tandon R.K. Subacute sclerosing panencephalitis: A clinical appraisal // Journal of Pediatric Neurosciences. — 2013. — Vol. 8, No. 3. — P. 176–181.
2. Garg R.K., Malhotra H.S., Jain A. Subacute sclerosing panencephalitis: current perspectives // Pediatric Neurology. — 2018. — Vol. 79. — P. 1–7.
3. Jafarpour S., et al. Subacute sclerosing panencephalitis: Recent advances in pathogenesis, diagnosis, and treatment // Cureus. — 2025.
4. Campbell H., et al. The neuroimaging spectrum of subacute sclerosing panencephalitis: a systematic review // Neuroradiology. — 2026. — DOI: 10.1007/s00234-026-04031-7.
5. Anlar B. Subacute sclerosing panencephalitis: diagnosis and drug treatment options // CNS Drugs. — 1997. — Vol. 7, No. 2. — P. 111–120. — DOI: 10.2165/00023210-199707020-00003.
6. Campbell H., Andrews N., Brown K.E., Miller E. Review of the effect of measles vaccination on the epidemiology of SSPE // International Journal of Epidemiology. — 2007. — Vol. 36, No. 6. — P. 1334–1339.
7. World Health Organization. Measles: Fact sheet. — Geneva: WHO, 2026.
8. World Health Organization. Subacute sclerosing panencephalitis and measles vaccination. Global Advisory Committee on Vaccine Safety. — Weekly Epidemiological Record. — 2005.
9. Wendorf K.A., et al. Subacute sclerosing panencephalitis: the devastating outcome of measles in the absence of vaccination // Clinical Infectious Diseases. — 2017. — Vol. 65, No. 2. — P. 226–232.
10. Singh R., et al. Movement disorders in patients with subacute sclerosing panencephalitis: a systematic review // Tremor and Other Hyperkinetic Movements. — 2024.
