IMMUNOGENETIC CHARACTERISTICS OF COVID-19 IN THE REPUBLIC OF KARAKALPAKSTAN
Ключевые слова:
SARS-CoV-2, immunogenetic features, Karakalpakstan, MTHFR gene, TNF geneАннотация
The clinical course and outcomes of COVID-19 are significantly modulated by host immunogenetic factors, particularly human leukocyte antigen (HLA) gene polymorphisms and cytokine gene variations. Regional immunogenetic profiling is essential for identifying ethnic-specific genetic susceptibility and protective mechanisms against severe SARS-CoV-2 infection. To investigate the immunogenetic characteristics, HLA allele frequency distribution, and cytokine gene polymorphisms in patients with COVID-19 in the Republic of Karakalpakstan, and to establish their association with disease severity and clinical outcomes
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