TUXUMDONLAR POLIKISTOZI SINDROMIGA BOG‘LIQ BEPUSHTLIKDA NUTRIENT-METABOLIK PROFILNING KLINIK-PATOGENETIK AHAMIYATI
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TPKS##common.commaListSeparator## bepushtlik##common.commaListSeparator## nutrientlar##common.commaListSeparator## oksidativ stress##common.commaListSeparator## insulinrezistentlikAbstrak
Tuxumdonlar polikistoz sindromiga (TPKS) bog‘liq bepushtlikda nutrient-metabolik buzilishlar muhim o‘rin tutadi. Ushbu maqolada vitamin D, rux, selen yetishmovchiligi, insulinrezistentlik va oksidativ stressning reproduktiv funksiyaga ta’siri yoritilgan. Maqsad: Tuxumdonlar polikistoz sindromiga (TPKS) bog‘liq bepushtlikda nutrient-metabolik profilning klinik-patogenetik ahamiyatini o‘rganish. Material va metodlar: Tadqiqotga TPKS bilan bog‘liq bepushtligi bo‘lgan 70 nafar ayol va 20 nafar sog‘lom ayol kiritildi. Qonda vitamin D, magniy, rux, selen, insulin, AMH va HOMA-IR ko‘rsatkichlari aniqlandi. Oksidativ stress markerlari — MDA va TAC baholandi. Natijalar: Asosiy guruhda nutrient yetishmovchiligi, insulinrezistentlik va oksidativ stress ko‘rsatkichlari nazorat guruhiga nisbatan sezilarli yuqori aniqlandi (p<0,05). Nutrient tanqisligi ovulyator buzilishlar va giperandrogeniya bilan bog‘liq ekanligi aniqlandi. Xulosa: Nutrient-metabolik buzilishlar TPKSga bog‘liq bepushtlik patogenezida muhim ahamiyatga ega
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