DIAGNOSTIC SIGNIFICANCE OF 3D RADIOLOGICAL VISUALIZATION OF THE PARANASAL SINUSES IN CHILDREN WITH CYSTIC FIBROSIS

Saodat Makhmudova; Nilyufar Khushvakova; Nargiza Khamrakulova

Authors

Saodat Makhmudova First-Year Basic Doctoral (PhD) Student, Department of Otorhinolaryngology No. 1, Samarkand State Medical University Author
Nilyufar Khushvakova Head of the Department of Otorhinolaryngology No. 1, Samarkand State Medical University, Doctor of Medical Sciences, Professor Author
Nargiza Khamrakulova Associate Professor, Department of Otorhinolaryngology No. 1, Samarkand State Medical University, Doctor of Medical Sciences Author

Keywords:

Cystic fibrosis, children, paranasal sinuses, three-dimensional visualization, radiological diagnosis

Abstract

This article discusses the diagnostic assessment of pathological changes in the nasal cavity and paranasal sinuses in children with cystic fibrosis using modern radiological imaging techniques. Impaired mucociliary clearance, accumulation of thick secretions, and chronic inflammatory processes associated with cystic fibrosis may contribute to various structural abnormalities of the sinonasal system. The article focuses on the diagnostic capabilities of three-dimensional radiological visualization in assessing the anatomy of the paranasal sinuses, mucosal changes, sinus opacification, hypoplasia, polypoid changes, and sinus drainage pathways. Three-dimensional reconstruction provides additional diagnostic information regarding the localization and extent of pathological processes, spatial relationships between anatomical structures, and treatment planning. The integration of three-dimensional radiological visualization with clinical and endoscopic examinations may improve the comprehensive assessment of sinonasal pathology in children with cystic fibrosis.

Downloads

Download data is not yet available.

References

1. Berkhout M.C., Klerx-Melis F.K., Fokkens W.J., Nuijsink M., van Aalderen W.M.C., Heijerman H.G.M. CT-abnormalities, bacteriology and symptoms of sinonasal disease in children with Cystic Fibrosis // Journal of Cystic Fibrosis. – 2016. – Vol. 15, No. 6. – P. 816–824.

2. Gergin O., Kawai K., MacDougall R.D., Robson C.D., Moritz E., Cunningham M., Adil E. Sinus Computed Tomography Imaging in Pediatric Cystic Fibrosis: Added Value? // Otolaryngology–Head and Neck Surgery. – 2016. – Vol. 155, No. 1. – P. 160–165.

3. Manzini M., Schweiger C., Manica D., Machado L.R., Lopes P.S.D., Sekine L., Faccin C.S., Piltcher O.B., Marostica P.J.C. Sinonasal computed tomography in pediatric cystic fibrosis: do we know the indications? // International Journal of Pediatric Otorhinolaryngology. – 2018. – Vol. 113. – P. 204–207.

4. Kang S. H., Piltcher O. B., Dalcin P. T. R. Sinonasal alterations in computed tomography scans in cystic fibrosis: a literature review of observational studies // International Forum of Allergy & Rhinology. 2014. Vol. 4, № 3. P. 223–231.

5. Ciet P., Booij R., Dijkshoorn M., van Straten M., Tiddens H. A. W. M. et al. Chest radiography and computed tomography imaging in cystic fibrosis: current challenges and new perspectives // Pediatric Radiology. 2023. Vol. 53. P. 649–659.

6. Çetin B. Anatomical Variations of the Nose and Paranasal Sinuses in Pediatric CBCT Scans: A Retrospective Analysis // Selcuk Dental Journal. 2025. Vol. 12, № 3. P. 409–414

7. Johansen H. K., Aanaes K., Pressler T. et al. Colonisation and infection of the paranasal sinuses in cystic fibrosis patients is accompanied by a reduced PMN response // Journal of Cystic Fibrosis. 2012. Vol. 11, № 6. P. 525–531.

8. Rasmussen J., Nielsen K. G., Høiby N. et al. CT of the paranasal sinuses is not a valid indication for sinus surgery in CF patients // Journal of Cystic Fibrosis. 2012. Vol. 11, № 5. P. 425–432.

9. Sommerburg O., Wucherpfennig K., Stahl M. et al. Sinonasal abnormalities in children with cystic fibrosis assessed by magnetic resonance imaging // European Radiology. 2020. Vol. 30. P. 6849–6858.

10. Polyakov D. P., Daykhes N. A., Yunusov A. S. et al. Rhinosinusosurgery in children with cystic fibrosis // Head and Neck Russian Journal. 2021. Vol. 9, № 1. P. 35–44.