ВЛИЯНИЕ ЖЕНСКИХ ПОЛОВЫХ ГОРМОНОВ НА ЦИТОКИНОВЫЙ ПРОФИЛЬ У БОЛЬНЫХ ЖЕНЩИН С РЕВМАТОИДНЫМ АРТРИТОМ

Салимова Г.Х; Халимова З.Ю; Набиева Д.А

Authors

Салимова Г.Х Ташкентский Государственный медицинский университет Author
Халимова З.Ю Республиканский специализированный научно-практический медицинский центр эндокринологии имени академика Ё.Х.Туракулова Author
Набиева Д.А Ташкентский Государственный медицинский университет Author

Keywords:

Ревматоид артрит

Abstract

Репродуктив ёшдаги РА билан оғриган аёлларда эстрадиол ва прогестерон даражасининг пасайиши яллиғланиш олди цитокинларининг гиперекспрессиясини кучайтирувчи омил ҳисобланади. Шу билан бирга, ҳайз циклининг иккинчи босқичида прогестероннинг физиологик ўсишининг йўқлиги уларнинг сезиларли даражада гиперекспрессиясига олиб келади. Ўз навбатида, бемор аёллар қон зардобида эстрадиол миқдорининг ўзгариши ИЛ-40 секрециясининг ортишига туртки беради.

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