GEPATORENAL SINDROMDA CAT VA TNF GEN MARKERLARINI LABORATOR ANIQLASH: ZAMONAVIY YONDASHUVLAR VA MUAMMOLAR
Keywords:
gepatorenal sindrom, CAT geni, TNF geni, gen polimorfizmi, C-262TAbstract
Tadqiqot maqsadi — gepatorenal sindrom (GRS) erta rivojlanishida CAT (rs1001179) genining C-262T va TNF genining G-308A polimorf markerlarining prognostik ahamiyatini baholash. Tadqiqotga GRS tashxisi qo'yilgan 90 nafar bemor (asosiy guruh) va 85 nafar sog'lom kishi (nazorat guruhi) kiritildi. Allel-spetsifik PCR usuli qo'llanildi. Natijalar shuni ko'rsatdiki, CAT genining T alleli asosiy guruhda 30,6%, nazorat guruhida 15,9% tarqalgan bo'lib, GRS rivojlanishi xavfini ishonchli darajada oshiradi (OR=2,3; 95% CI 1,4–3,89; p=0,01). C allel himoyalovchi omil sifatida aniqlandi (OR=0,4; 95% CI 0,26–0,72). TNF genining A alleli asosiy guruhda 10,6%, nazorat guruhida 5,3% uchrab, kasallik xavfini oshirdi (OR=2,1; 95% CI 0,94–4,73). G/G genotipi protektiv xususiyatga ega (OR=0,4; 95% CI 0,19–1,03). Xulosa: ushbu genetik markerlar GRS xavfi ostidagi bemorlarni erta aniqlashda muhim diagnostik ahamiyat kasb etadi.
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References
1. Angeli P., Gines P., Wong F. et al. Diagnosis and management of acute kidney injury in patients with cirrhosis // Journal of Hepatology. — 2015. — Vol. 62. — P. 968–974.
2. Arroyo V., Ginès P., Gerbes A.L. et al. Definition and diagnostic criteria of refractory ascites and hepatorenal syndrome in cirrhosis // Hepatology. — 1996. — Vol. 23(1). — P. 164–176.
3. Jabbarov, A. A. 11-7 (81) 2025-Jabbarov AA, Samadova A.-PROGNOSTIC ROLE OF SERUM CYSTATIN C IN THE EARLY DETECTION OF HEPATORENAL SYNDROME AMONG CIRRHOTIC INDIVIDUALS.
4. Samadova, A., & Djabbarova, Z. I. (2026). GEPATORENAL SINDROMNI ERTA TASHXISLASH VA DAVOLASHDA ILG ‘OR TIBBIY TEXNOLOGIYALAR. GLOBAL RESEARCH AND ACADEMIC INNOVATIONS, 2(1), 323-332.
5. Саттарова, Н. А., & Самадова, А. Б. (2026). ХРОНИЧЕСКИЙ ГЕПАТИТ И ХРОНИЧЕСКАЯ БОЛЕЗНЬ ПОЧЕК: КЛИНИКО-ЛАБОРАТОРНЫЕ АСПЕКТЫ, СОВРЕМЕННЫЕ ПОДХОДЫ К ДИАГНОСТИКЕ И ЛЕЧЕНИЮ. FRONTIERS OF KNOWLEDGE AND INTERDISCIPLINARY DISCOVERY, 2(1), 336-344.
6. Анагул, С., & Шахло, Ю. (2026). СОВРЕМЕННЫЕ ПОДХОДЫ К РАННЕМУ ВЫЯВЛЕНИЮ И ТЕРАПИИ ГЕПАТОРЕНАЛЬНОГО СИНДРОМА. FRONTIERS OF KNOWLEDGE AND INTERDISCIPLINARY DISCOVERY, 2(1), 326-335.
7. Samadova, A. (2025). CLINICAL AND LABORATORY ASSESSMENT OF RENAL DYSFUNCTION IN LIVER CIRRHOSIS. South Aral Region Medical Journal, 1(1), 126-130.
8. Ataxonovich, J.A., Samadova, A. and Maratovna, D.D., 2024. MODERN TREATMENT METHODS FOR HEPATORENAL SYNDROME. Web of Medicine: Journal of Medicine, Practice and Nursing, 2(12), pp.147-154.
9. Ruzmetov, N. A., A. B. Samadova, and Q. F. Abdullayev. "DIAGNOSIS OF KIDNEY DAMAGE AND CHRONIC KIDNEY DISEASE AFTER LIVER DISEASES AMONG THE POPULATION OF KHOREZM REGION." Talqin va tadqiqotlar ilmiy-uslubiy jurnali 2.56 (2024): 235-240.
10. Ataxonovich, Jabbarov Azimboy, and Shegay Olga Alekseyevna. "HEPATORENAL SYNDROME PREDICTORS OF CLINICAL, PATHOGENETIC, AND GENETIC FACTORS." Western European Journal of Medicine and Medical Science 2.12 (2024): 20-27.
11. Ataxonovich, J.A., Samadova, A. and Gulxayo, P., 2025. NEW MEDICAL TECHNOLOGIES FOR 14.EARLY DIAGNOSIS AND TREATMENT OF HEPATORENAL SYNDROME. Multidisciplinary Journal of Science and Technology, 5(3), pp.262-267.
12. Ataxonovich, J.A., Samadova, A. and Maratovna, D.D., 2025. Advancements in the Diagnosis and Treatment of Hepatorenal Syndrome: The Role of Modern Medical Technologies. Multidisciplinary Journal of Science and Technology, 5(3), pp.392-396.
