THERAPEUTIC POTENTIAL OF GINGER EXTRACT IN MITIGATING SECONDARY IMMUNODEFICIENCY AND HEMATOLOGICAL DYSFUNCTIONS IN A MURINE MODEL OF ACUTE TOXIC HEPATITIS
Abstract
Environmental xenobiotics and various disruptive factors frequently compromise immune system integrity, leading to secondary immunodeficiencies and hematological abnormalities. Plant-based immunomodulators are increasingly recognized for their low toxicity and multifaceted therapeutic potential. This study investigates the immunomodulatory and hematopoietic corrective properties of ginger extract in vivo.
Downloads
References
1. Balykova, L.A., Gerasimova, N.G., Dzyubich, L.I., et al. (2010). Immunorehabilitation of children frequently ill with respiratory infections. Practical Medicine, 45, 137-140.
2. Borshchuk, E.L., Popov, Yu.N., Sankov, A.N. (2016). Analysis of immunomodulators in the pharmaceutical market. Bulletin of Orenburg State Agrarian University, 3(59), 218-221.
3. Bulovskaya, L.N., Borisenko, G.N., Drobachenko, O.A. (1990). Determination of N-acetyltransferase activity phenotype. Leningrad, 10, 28-31.
4. Gadzhieva, T.A., Kudaev, M.T., Makhmudova, E.R., et al. (2018). Environmental risk factors and their impact on bronchial asthma morbidity in Dagestan. Journal of New Medical Technologies. Electronic edition, 12(1), 87-93.
5. Goldobin, D.D., Loktionov, A.L., Bystrova, N.A., et al. (2017). Immune disorders at systemic and local levels in chronic periodontitis, correlation with oxidative changes. Immunology, 38(1), 35-39.
6. Zakharova, D.A., Balukhto, D.A., Budina, D.V., et al. (2018). Clinical and immunological features of secondary immune insufficiency in people of different ages. Smolensk Medical Almanac, 1, 118-120.
7. Ismailov, I.Z., Zurdinov, A.Z., Sabirova, T.S. (2017). Development and application of immunomodulators at the present stage: problems and prospects. Scientific Journal, 1(14), 83-87.
8. Konoplya, A.I., Shatokhin, M.N., Mavrin, M.Yu., et al. (2017). Interrelation of immune and oxidative disorders in acute non-obstructive and obstructive pyelonephritis. Clinical Medicine, 95(4), 362-368.
9. Mirkhaidarov, A.M., Farkhutdinov, U.R., Farkhutdinov, R.R. (2016). Immune status of patients with community-acquired pneumonia and the effectiveness of immunovenin in complex therapy. Medical Bulletin of Bashkortostan, 11(2), 12-15.
10. Petrov, E.V., Aseeva, T.A., Chekhirova, G.V. (2009). Theoretical prerequisites for the development of formulations of multicomponent phytopreparations based on the experience of traditional medicine. Acta Biomedica Scientifica, 3, 222-224.
11. Ryabkova, V.A., Churilov, L.P., Schoenfeld, Y. (2020). Hyperstimulation of the immune system as a cause of autoimmune diseases. Annals of the Russian Academy of Medical Sciences, 75(3), 204-213.
12. Sambukova, T.V., Ovchinnikov, B.V., Ganapolsky, V.P., et al. (2017). Prospects for the use of phytopreparations in modern pharmacology. Reviews on Clinical Pharmacology and Drug Therapy, 15(2), 55-62.
13. Troshina, E.A. (2020). Immunoendocrinology - issues and challenges of today. Problems of Endocrinology, 66(4), 4-8.
14. Bogatov, V.V., Baklanov, P.Ya., Lozovskaya, S.A., et al. (2021). Climate change and health in the Russian Far East. Bulletin of the Far Eastern Branch of the Russian Academy of Sciences, 1(215), 5-21.
15. Bychkova, N.G., Bychkov, O.A. (2017). Immune and cytokine related disorders, aortic stiffness index in patients with arterial hypertension combined to gout. Eastern European Scientific Journal, 8-1(24), 15-19.
16. Fatimawali, F., Kalalo, M., Broolin, S., et al. (2022). Immunomodulatory potential of bioactive compounds of betel leaf extract targeting COVID-19 immunological human host proteins: An in silico study. Journal of Applied Pharmaceutical Science.
17. Jantan, I., Ahmad, W., Bukhari, S.N.A. (2015). Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Frontiers in Plant Science, 6, 1-18.
18. Jerne, N.K., Nordin, A.A. (1963). Plaque formation in agar by single antibody-producing cells. Science, 140, 405-407.
19. Khanna, K., Kohli, S.K., Kaur, R., et al. (2020). Herbal immune-boosters: Substantial warriors of pandemic Covid-19 battle. Phytomedicine, 85, 153361.
20. Kibatayev, K.M., Sakhanova, S.K., Urgushbayeva, G.M., et al. (2018). The review of actual ecological situation in Aktobe region. West Kazakhstan Medical Journal, 4(60), 18-22.
21. Kurolap, S.A., Klepikov, O.V., Vinogradov, P.M., et al. (2016). Regional geographic information systems of health and environmental monitoring. Baltic Region, 8(4), 108-124.
22. Mahima, Ingle, A.M., Verma, A.K., et al. (2013). Immunomodulators in day to day life: a review. Pakistan Journal of Biological Sciences, 16(17), 826-843.
23. Marciani, D.J. (2017). Effects of immunomodulators on the response induced by vaccines against autoimmune diseases. Autoimmunity, 50(7), 393-402.
24. Munafò, A., Burgaletto, C., Benedetto, D., et al. (2020). Repositioning of Immunomodulators: A Ray of Hope for Alzheimer’s Disease? Frontiers in Neuroscience, 4(14), 614-643.
25. Robinson, M.M., Zhang, X. (2011). The World Medicines Situation 2011. Traditional Medicines: Global Situation, Issues and Challenges, 3, 14.
26. Rölle, A., Brodin, P. (2016). Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMV. Trends in Immunology, 37(3), 233-243.
27. Sengupta, S., Bhattacharyya, D., Kasle, G., et al. (2021). Properties of Biologically Active Components of Spices Against SARS-CoV-2 and Pan β-Coronaviruses. Frontiers in Cellular and Infection Microbiology, 11, 729622.
28. Sicherer, S.H., Sampson, H.A. (2014). Food allergy: Epidemiology, pathogenesis, diagnosis, and treatment. The Journal of Allergy and Clinical Immunology, 133(2), 291-307.
29. Wainwright, C.L., Teixeira, M.M., Adelson, D.L., et al. (2022). Future directions for the discovery of natural product-derived immunomodulating drugs: an IUPHAR positional review. Pharmacological Research, 177, 106.
30. Walaa, N.A. (2017). Immunomodulatory and Natural Immunomodulators. J Allergy and Inflammation, 1(2), 1-4.



















