CHANGES IN CYTOKINE PROFILE IN HEPATITIS A: THE CONNECTION BETWEEN INFLAMMATION AND REGENERATION

Ikrom Artikov; Donokhan Mirzajonova

Authors

Ikrom Artikov Urganch State Medical Institute, assistant of the Department of Infectious Diseases, Epidemiology and Phthisia, Urgench, Uzbekistan Author
Donokhan Mirzajonova Tashkent State Medical University, Associate Professor, Department of Infectious and Pediatric Infectious Diseases, Doctor of Medical Sciences, Tashkent, Uzbekistan Author

Keywords:

viral hepatitis, immune system, liver, cachexin, growth factor

Abstract

Changes in TNF-α and HGF levels have been identified in hepatitis A, demonstrating a link between inflammation and regeneration. An increase in TNF-α indicates its role as an inflammatory mediator, while an increase in HGF reflects a response to hepatocyte destruction and stimulates their proliferation for liver repair. Higher HGF levels are associated with greater liver damage and the need for active repair.

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