IMPROVING THE CRITERIA FOR EARLY DIAGNOSIS OF HYDATIDIFORM MOLE AND RISK STRATIFICATION IN THE ARAL SEA REGION

Quvonchoy Madrimova; Daniyar Nishonov

Authors

Quvonchoy Madrimova Urganch davlat tibbiyot instituti. Assistent Author
Daniyar Nishonov RepublikaPatologik anatomiya markazi directori Author

Keywords:

hCG antibodies

Abstract

Abstract: Recent advances in cellular biology and diagnostic technology have improved gynecological disease management and fertility preservation. Early detection of conditions like hydatidiform mole is linked to better outcomes, while appropriate treatment and careful monitoring increase the chances of a successful pregnancy and healthy childbirth.

Aim: To evaluate the role of immunohistochemical analysis in detecting malignant transformation of hydatidiform mole in women residing in the Aral region and to develop a comprehensive management algorithm for these patients.

Study design: An open-label, independent prospective study.

Materials and methods: A total of 70 endometrial aspirate samples from women diagnosed with hydatidiform mole were analyzed. The samples were collected between 2019 and 2022.

Conclusion: Successful pregnancy outcomes require precise regulation and interaction between specific hormones and their respective receptors. Dysregulation or aberrant expression within any of these pathways may lead to implantation failure or pregnancy loss.

Downloads

Download data is not yet available.

References

1. E.K. Aylamazyan, V.E. Radzinsky. “Prevention of Complications in Early Pregnancy”, CyberLeninka, 2020. (from Russian).

2. ESHRE Guideline Group on RPL; Bender Atik R., Christiansen O.B., et al. ESHRE Guideline: Recurrent Pregnancy Loss – An Update in 2022. Hum Reprod Open. 2023; 2023(1): hoad002. DOI: 10.1093/hropen/hoad002.

3. G.A. Ikhtiyarova, N.K. Dustova, Sh.U. Bakhramova, N.Kh. Ruziyeva, D.S. Irgashev, G.Zh. Matrizayeva. “Molecular Genetic Markers of Hypertension Risk in Pregnant Women with Antiphospholipid Syndrome”, Clinical Case Review in General Medicine. 2024; 5(9). (from Russian).

4. G.D. Matrizayeva, G.A. Ikhtiyarova. “Pathomorphological and Immunohistochemical Characteristics of Recurrent Pregnancy Loss in the First Trimester”, Uzbekistan Medical Journal No. 4, 2024. Tashkent, 2024. (from Uzbek).

5. J.J. Candelier. “The Hydatidiform Mole”, Cell Adhesion & Migration, 2016, 10(1–2), 226–235. DOI: 10.1080/19336918.2015.1093275.

6. K.K. Madrimova, D.A. Nishonov, G.D. Matrizayeva. “Immunohistochemical Diagnosis of Hydatidiform Mole Occurring in the First Trimester of Pregnancy”, Biologiya va Tibbiyot Muammolari 2024, No. 1 (151), pp. 168-171. (from Russian).

7. K.K. Madrimova, Kh.S. Ikramova. “Diagnosis of Hydatidiform Mole. News in Dermatovenereology and Reproductive Health”, Central Asian Scientific and Practical Journal. No. 1-2, 2024 (105), pp. 59-61. (from Russian).

8. L. Cue, F. Farci, S. Ghassemzadeh. “Hydatidiform Mole”. Treasure Island (FL): StatPearls Publishing; 2025 Jan.

9. M.G. Marini. “Effects of Platelet-Rich Plasma in a Model of Bovine Endometrial Inflammation In Vitro”. Reprod Biol Endocrinol, 2016. DOI: 10.1186/s12958-016-0195-4.

10. V.E. Radzinsky. “Recurrent Pregnancy Loss: A Social Problem and Medical Solutions”, CyberLeninka, 2021. (from Russian).

11. V.V. Kuznetsov, L.A. Meshcheryakova, S.V. Khokhlova. “Clinical Guidelines for the Diagnosis and Treatment of Malignant Placental Neoplasms”, All-Russian Union of Public Organizations of the Association of Oncologists of Russia. Page 16. (from Russian).

12. Y.E. Dobrokhotova, S.E. Arakelov, S.Zh. Danelian, E.I. Borovkova. “Hydatidiform Mole: A Clinical Case of Pregnancy Management”, CyberLeninka, 2019. (from Russian).