OSHQOZON-ICHAK TIZIMIDA DORI VOSITALARINING SO‘RILISHI: FARMAKOKINETIK OMILLAR, KLINIK XAVFLAR VA DIFFERENSIAL BAHOLASH
Keywords:
dori so‘rilishi, bioavailability, farmakokinetika, oshqozon pH, ichak fermentlariAbstract
Ushbu maqolada oshqozon-ichak tizimida dori vositalarining so‘rilishi farmakokinetik jarayon sifatida tahlil qilindi. Og‘iz orqali qabul qilinadigan preparatlarning klinik samarasi faqat farmakodinamik faollikka emas, balki preparatning erishi, oshqozon pH muhitida barqarorligi, ichak epiteliysidan o‘tishi, fermentlar va transport oqsillari bilan o‘zaro ta’siri, ovqat hamda boshqa dori vositalari ta’sirida o‘zgarishiga ham bog‘liq. Maqolada bioavailability tushunchasi, birinchi o‘tish metabolizmi, pHga bog‘liq eruvchanlik, xelatlanish, P-glikoprotein va ichak fermentlari kabi omillar klinik nuqtayi nazardan izohlandi. Natijalar shuni ko‘rsatadiki, oshqozon-ichak so‘rilishini e’tiborsiz qoldirish davolash samaradorligining pasayishi, toksiklik, nojo‘ya ta’sirlar yoki polifarmatsiya bilan bog‘liq xavflarni kuchaytiradi. Hududiy infratuzilma ma’lumotlari esa farmakoterapiya monitoringi barcha hududlarda bir xil tashkiliy darajada olib borilishi zarurligini ko‘rsatadi.
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