YANGI POLIFENOL KOMPLEKSI (PK-12) NING EKSPERIMENTAL OʻTKIR TOKSIK GEPATOPATIYALARDA SITOPROTEKTIV VA ANTIOKSIDANT SAMARADORLIGINI BAHOLASH
Ключевые слова:
Gepatoprotektor, polifenol kompleksi, tetraxloruglerod, lipidlar peroksidatsiyasi, superoksiddismutazaАннотация
Turli etiologiyali gepatotoksik shikastlanishlar, xususan, ksenobiotiklar va dori vositalari keltirib chiqaradigan gepatopatiyalar zamonaviy gastroenterologiya va farmakologiyaning dolzarb muammolaridan biridir. Mavjud gepatoprotektorlarning nojoʻya taʼsirlari hamda past biomavjudligi tabiiy polifenollar asosida yangi, yuqori samarali sitoprotektorlarni yaratishni taqozo etadi.
Tadqiqot maqsadi: Wistar zotli kalamushlarda tetraxloruglerod (CCl₄) taʼsirida chaqirilgan oʻtkir toksik gepatit modelida yangi PK-12 polifenol kompleksining sitoprotektiv, membranani barqarorlashtiruvchi va antioksidant taʼsir mexanizmlarini qiyosiy baholash
##plugins.themes.default.displayStats.downloads##
Библиографические ссылки
1. European Association for the Study of the Liver (EASL). EASL Clinical Practice Guidelines: Drug-induced liver injury. J Hepatol. 2019;70(6):1222-1261.
2. Andrade RJ, Chalasani N, Björnsson ES, et al. Drug-induced liver injury. Nat Rev Dis Primers. 2019;5(1):58.
3. Chalasani NP, Hayashi PH, Bonkovsky HL, et al. ACG Clinical Guideline: the diagnosis and management of idiosyncratic drug-induced liver injury. Am J Gastroenterol. 2014;109(7):950-966.
4. Cichoż-Lach H, Michalak A. Oxidative stress as a crucial factor in liver diseases. World J Gastroenterol. 2014;20(25):8082-8091.
5. Knockaert L, Berson A, Ribault C, et al. Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in rat liver. Lab Invest. 2012;92(3):396-410.
6. Weber LW, Boll M, Stampfl A. Hepatotoxicity and mechanism of action of haloalkanes: carbon tetrachloride as a toxicological model. Crit Rev Toxicol. 2003;33(2):105-136.
7. Gillessen A, Schmidt HH. Silymarin as a Supportive Treatment in Liver Diseases: A Narrative Review. Adv Ther. 2020;37(4):1279-1301.
8. Popov SV, Krivoruchko EV. Sovremennye gepatoprotektory rastitelnogo proiskhojdeniya: effektivnost i mekhanizmy deystviya. Eksp Klin Farmakol. 2021;84(3):42-48.
9. Zhang M, Zhu J, Zhang X, et al. Hepatoprotective effects of plant polyphenols: A comprehensive review on molecular mechanisms. Phytomedicine. 2023;112:154689.
10. Popovic M, Kaurinovic B, Trivic S, et al. Effect of flavonoids on carbon tetrachloride-induced hepatotoxicity in rats. Molecules. 2021;26(11):3241.
11. Manibusan MK, Odin M, Eastmond DA. Postulated carbon tetrachloride mode of action: a review. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2007;25(3):185-209.
12. Boll M, Weber LW, Becker E, Stampfl A. Pathogenesis of carbon tetrachloride-induced hepatocyte injury. Bioactivation of CCl₄ by cytochrome P450 2E1. Z Naturforsch C J Biosci. 2001;56(1-2):111-121.
13. Jaeschke H, McGill MR, Ramachandran A. Oxidant stress, mitochondria, and cell death mechanisms in drug-induced liver injury: Lessons from acetaminophen and beyond. Liver Res. 2018;2(2):76-86.
14. Abenavoli L, Capasso R, Milic N, Capasso F. Milk thistle in liver diseases: past, present, future. Phytother Res. 2010;24(10):1423-1432.
15. Bellezza I, Giambanco I, Minelli A, Donato R. Nrf2-Keap1 signaling in oxidative and reductive stress. Biochim Biophys Acta Mol Cell Res. 2018;1865(5):721-733.
16. Xu D, Xu M, Broadhurst R, et al. Polyphenols protect against acetaminophen-induced hepatotoxicity via activation of Nrf2 antioxidant pathway. Antioxidants. 2022;11(6):1154.
17. Mamadalieva NZ, Youssef FS, Ashour ML, et al. Flavonoids and polyphenols from Central Asian flora: Hepatoprotective potential and phytochemistry. Fitoterapia. 2021;153:104987.
18. Karimov AM, Inoyatova FKh. Farmakologicheskaya korrektsiya toksicheskogo porajeniya pecheni rastitelnymi polifenolami. Eksperimentalnaya i Klinicheskaya Farmakologiya. 2022;85(4):34-39.
19. Wang Y, Gao H, Zhang W, et al. Protective mechanism of natural flavonoid complexes in hepatic ischemia-reperfusion and toxic injuries. Biomed Pharmacother. 2024;170:115982.
20. Al-Rasheed NM, Faddah LM, Mohamed AM, et al. Protective effects of silymarin and polyphenolic fraction against carbon tetrachloride-induced hepatotoxicity. Afr J Pharm Pharmacol. 2016;10(9):142-151.
