IMMUNOHISTOCHEMICAL EXAMINATION OF GASTRIC TISSUE IN LIVER INJURY UNDER EXPERIMENTAL CONDITIONS

Rakhmon Davronov; Norbek Xolboev

Authors

Rakhmon Davronov Candidate of Medical Sciences, Associate Professor, Department of Histology, Cytology, and Embryology Bukhara State Medical Institute named after Abu Ali ibn Sino, Uzbekistan, Bukhara, A.Navoiy street Author
Norbek Xolboev Termez University of Economics and Service Department of Therapeutic Sciences Surkhandarya, Termez, Uzbekistan Author

Keywords:

liver injury, stomach, immunohistochemical examination, rats

Abstract

The expression of the Ki-67 proliferation marker is an important criterion for assessing the proliferative activity of gastric mucosa cells. During the study, the level of immunohistochemical expression of the Ki-67 marker in the gastric tissues of 3 and 6-month-old white crossbred rats with liver injury in the control group and experimental conditions was studied. In the gastric mucosa of 3–6-month-old white crossbred rats in the control group, it was observed that Ki-67 positive cells were mainly located in the proliferative zones of the glands, especially in the neck. The expression of the marker at a physiological level indicated that the natural renewal processes of gastric epithelial cells were preserved. The presence of the Ki-67 index at a normal level indicates that the balance between cell proliferation and apoptotic processes is maintained. It was found that the expression of the Ki-67 marker in the stomach of rats 3 months after experimentally induced liver injury significantly increased compared to the control group. This phenomenon was assessed as a compensatory-regenerative response to the dystrophic and inflammatory changes that developed in the gastric mucosa.

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