ICHAK MIKROBIOTASI VA UNING OIV INFEKSIYASI BILAN BOG‘LIQ BAKTERIOLOGIK TAHLILI
Ключевые слова:
ichak mikrobiomi, OIV-infeksiyali bemorlar, bifidobakteriya, laktobakteriya, disbiozАннотация
Maqolada OIV-infeksiyali bemorlar va amaliy sog’lomlar ichak mikrobiomi o’rtasida taqqoslovchi meta tahlil o’tkazilib, ichak mikroflorasining tuzilma va funksional xususiyatlari o’rganilgan. OIV-infeksiyali bemorlarda immunodefitsit va antiretrovirus terapiya ta’siri bilan bog’liq holda mikrobiom tarkibida sezilarli o’zgarishlar qayd etilgan. Bu o’zgarishlar dominant bakteriyalar (bifidobakteriyalar, laktobakteriyalar) funksional faolligining pasayishi hamda shartli-patogen mikroorganizmlar (jumladan, Enterobacteriaceae oilasi va Candida zamburug’lari) sonining ortishi bilan namoyon bo’ladi. OIV-infeksiyali bemorlarda mikrobiologik muvozanat disbioz tomonga siljishi aniqlangan bo’lib, bu yallig’lanish jarayonlarining kuchayishiga olib keladi va probiotik hamda prebiotiklardan foydalangan holda kompleks mikrobiokorreksiyani talab etadi. Tadqiqot OIV-infeksiyali bemorlarda immun gomeostazini saqlash va hayot sifatini yaxshilash uchun o’z vaqtida monitoring va qo’llab-quvvatlovchi terapiya muhimligini ta’kidlaydi.
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Библиографические ссылки
1. Ivashkin V.T. Inson mikrobiomi klinik amaliyotda. Rossiya jurnali gastroenterologiya, gepatologiya, koloproktologiya. 2017, 6 (27): 4–13.
2. Gapon M.N., Ternovskaya L.N. Lokal antioksidant indeksni hisoblash asosida ichak mikroekologik buzilishlari darajasini aniqlash. Jurnal mikrobiologii. 2016, 2: 80-84.
3. Bukharin O.V., Ivanova E.V., Perunova N.B. Inson ichagi immun gomeostazini bifidobakteriyalar metabolitlari orqali mikroblarni tanib olish sharoitida boshqarish. Jurnal mikrobiologii. 2017, 3:12–18.
4. Bovbel I.E. Zamonaviy tasavvurlar ichak mikrobiotasi va pediatr-shifokor amaliyotida probiotiklardan samarali foydalanish imkoniyatlari haqida. Meditsinskiye novosti. 2017, 2 (269): 25–31.
5. Buckley A., Turner J.R. Tight junction hujayra biologiyasi, to’siq regulyatsiyasi va shilliq qavat kasalliklari. Cold Spring Harbor Perspectives in Biology. 2018, 10: a029314.
6. Burgener A., McGowan I., Klatt N.R. OIV va shilliq qavat to’siqlari o’zaro ta’siri: yuqish va patogenez oqibatlari. Current Opinion in Immunology. 2015; 36: 22–30. https://doi.org/10.1016/j.coi.2015.06.004
7. Cai R., Cheng C., Chen J., Hu H., Ding C., Gu B. Yo’g’on ichakdagi shilliq qatlam bilan kommensal va patogen mikroorganizmlarning o’zaro ta’siri. Gut Microbes. 2020, 11: 680–690
8. Goloshchapov, O. V. Possible role of intestinal human viruses and bacteriophages following hematopoietic stem cell transplantation: a mini-review / O. V. Goloshchapov, A. B. Chukhlovin, O. S. Glotov // Cellular Therapy and Transplantation. – 2021. – Vol. 10, No. 4. – P. 19-25. – DOI 10.18620/ctt-1866-8836-2021-10-3-4-19-25. – EDN CWOJBR.
9. Khasanova G. M., Urunova D. M., Akhmedzhanova Z. I., Giyasova G. M., Chernikova A. A., Khasanova A. N. Gastrointestinal tract damage in HIV infection // Perm Medical Journal. 2019. No. 3. Pp. 24-28. DOI: 10.17238/PmJ1609-1175.2019.3.24–28 (In Russ.)].
10. Khasanova G. R., Bikkinina O. I., Anokhin V. A., Anikhovskaya I. A., Yakovlev M. Yu. Intestinal factor of HIV infection progression // Advances in Modern Biology. 2020. Vol. 140, No. 3. Pp. 278-288. DOI: 10.31857/S0042132420030059 (In Russ.)].
11. Altın, K. H. Alteration of Gut microbiota during HIV infection / K. H. Altın // Bioengineering Studies. – 2023. – Vol. 4, No. 1. – P. 9-15. – DOI: 10.37868/bes.v4i1.id247.
12. Guillo, L. Impact of HIV Infection on the Course of Inflammatory Bowel Disease and Drug Safety Profile: A Multicenter GETAID Study / L. Guillo, M. Uzzan, L. Beaugerie [et al.] // Clinical Gastroenterology and Hepatology. – 2022. – Vol. 20, Issue 4. – P. 787-797. – DOI: 10.1016/j.cgh.2020.12.023.
13. Novikova V. P., Polunina A. V. Composition of intestinal microbiota in COVID infection (scientific review) // Preventive and Clinical Medicine. 2020. No. 4(77). Pp. 81-86. DOI: 10.47843/2074-9120_2020_4_81. EDN KTGSDF (In Russ.)].
14. Asowata, O. E. Irreversible depletion of intestinal CD4+ T cells is associated with T cell activation during chronic HIV infection / O. E. Asowata, A. Singh, A. Ngoepe [et al.] // JCI Insight. – 2021. – Vol. 6, No. 22. – P. 1-18. – DOI: 10.1172/jci.insight.146162.
15. Crakes, K. R. Gut Microbiome Alterations During HIV/SIV Infection: Implications for HIV Cure / K. R. Crakes, G. Jiang // Frontiers in Microbiology. – 2019. – Vol. 10. – P. 1-10. – DOI: 10.3389/fmicb.2019.01104.
16. Kozorez E. I., Stoma I. O. Intestinal microbiome in HIV-infected patients // Clinical Infectology and Parasitology. 2024. Vol. 13, No. 3. Pp. 348-358. DOI 10.34883/PI.2024.13.3.037. EDN HVPLCK (In Russ.)].
17. Campos-Varela I., Dodge J.L., Terrault N.A., Brandman D., Price J.C. OIV bilan yashovchilarda virusga bog’liq bo’lmagan jigar kasalliklari AQSHda jigar transplantatsiyasining yetakchi sababi. American Journal of Transplantation. 2021; 21(9): 3148–3156. https://doi.org/10.1111/ajt.16569
18. Saviglia G.P., Rosso C., Ribaldone D.G. va boshq. Ichak to’sig’i patofiziologiyasi va zonulin roli. Minerva Biotecnologica. 2019, 31: 83–92.
19. Dubourg G. OIV-infeksiyalangan shaxslar mikrobiomi. Microbial Pathogenesis. 2017, 106: 85–93.
20. Fianchi F., Liguori A., Gasbarrini A., Grieso A., Miele L. Alkoholsiz yog’li jigar kasalligi – ichak–jigar o’qi modeli. International Journal of Molecular Sciences. 2021; 22(12): 6485. https://doi.org/10.3390/ijms22126485
21. Graziani C., Talocco C., De Sire R. va boshq. Ichak o’tkazuvchanligi: fiziologik va patologik holatlar. European Review for Medical and Pharmacological Sciences. 2019, 23: 795–810.
22. Hunt P.W., Sinclair E., Rodriguez B. va boshq. Ichak epitelial to’siq disfunksiyasi va tug’ma immun faollashuv davolanayotgan OIV-infeksiyada o’limni bashorat qiladi. Journal of Infectious Diseases. 2014; 210(8):1228–1238. https://doi.org/10.1093/infdis/jiu238
23. Hyun J., McMahon R.S., Lang A.L. va boshq. OIV va OGV yallig’lanish javoblarini kuchaytiradi. PLoS Pathogens. 2019; 15(7): e1007883.
24. Johansson M.E.V., Hansson G.C. Ichak shilliq qavati va musinlarning immunologik jihatlari. Nature Reviews Immunology. 2016, 16: 639–649.
25. D'Angelo C, Reale M, Costantini E. Microbiota and Probiotics in Health and HIV Infection. Nutrients. 2017;9(6):615. doi:10.3390/nu9060615
26. Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science. 2012;336(6086):1268–1273. doi:10.1126/science.1223490
27. Bäumler AJ, Sperandio V. Interactions between the microbiota and pathogenic bacteria in the gut. Nature. 2016;535(7610):85–93. doi:10.1038/nature18849
28. Rajasuriar R, Wright E, Lewin SR. Impact of antiretroviral therapy (ART) timing on chronic immune activation/inflammation and end-organ damage. Curr Opin HIV AIDS. 2015;10(1):35–42. doi:10.1097/COH.00000000000001225
29. Pelaseed T. va boshq. Ichak shilliq qavati birlamchi himoya chizig’i. Immunology Reviews. 2014, 260: 8.
30. Pembroke T., Deschenes M., Lebouche B. va boshq. OIVda gepatik steatoz tezroq rivojlanadi. Journal of Hepatology. 2017; 67(4): 801–808.
31. Quigley E.M.M. “Leaky gut” -tushuncha yoki klinik holatmi? Current Opinion in Gastroenterology. 2016, 32: 74–79.
32. Serrano-Villar S., Sainz T., Lee S.A. va boshq. Past CD4/CD8 nisbati va no-AIDS mortaliteti. PLoS Pathogens. 2014; 10(5): e1004078.
33. Tripathi A., Debelius J., Brenner D.A. va boshq. Ichak–jigar o’qi va mikrobiom. Nature Reviews Gastroenterology & Hepatology. 2018; 15(7): 397–411.
34. Tuychiyev L.N., Nuruzova Z.A., Mamatmusaeva F.Sh., Mo’minova M.A. OIV-infeksiyali bemorlarda mikrobiota o’zgarishlari. Gumanitar va tabiiy fanlar jurnali. 2025, №23(06), 2-jild: 259–268.
35. WHO, 2024. HIV/AIDS [WWW Document]. URL https:// https://www.who.int/teams/global-hivhepatitis-and-stis-programmes/hiv/strategicinformation/hiv-data-and-statistics
36. Muminova M.T., Mamatmusaeva F.Sh. O’tkir diareyali OIV zararlangan bolalarda fakultativ mikroflora. Toshkent tibbiyot akademiyasi axborotnomasi. 2023, 1-son: 122–124.
37. CDC, 2019b. Opportunistic Infections | Living with HIV | HIV Basics | HIV/AIDS CDC [WWW Document]. Cent. Dis. Control Prev. URL https://www.cdc.gov/ hiv/basics/livingwithhiv/opportunisticinfecti ons. html (accessed 5.7.19) 2025. №10-1.
38. Jason M. Brenchley, Sergio Serrano Villar/ From dysbiosis to defense: harnessing the gut microbiome in HIV/SIV therapy// BMC., Microbiome (2024) 12:113 https://doi.org/10.1186/ s40168 024 01825 w.,1-16pp
39. Sobczyk, J., Jain, S., Sun, X., Karris, M., Wooten, D., Stagnaro, J., Reed, S., 2020. Comparison of Multiplex Gastrointestinal Pathogen Panel and Conventional Stool Testing for Evaluation of Patients with HIV Infection. Oxford Univ. Press behalf Infect. Dis. Soc. Am. 7, 1–6.
40. Masoud Mortezazadeh et all., The effect of oral probiotics on CD4 count in patients with HIV infection undergoing treatment with ART who have had an immunological failure., Immunity, Inflammation and Disease., Received: 9 December 2022 | Revised: 28 May 2023 | Accepted: 29 May 2023., DOI: 10.1002/iid3.913 3
41. Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, et al. CD4+ T-cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med. 2004;200(6):749–759. doi:10.1084/jem.20040874
42. Carter GM, Esmaeili A, Shah H, Indyk D, Johnson M, Andreae M, Sacks HS. Probiotics in Human Immunodeficiency Virus Infection: A systematic review and evidence synthesis of benefits and risks. Open Forum Infect Dis. 2016;3(4):ofw164. doi:10.1093/ofid/ofw164
3543. Peterson LW, Artis D. Intestinal epithelial cells: Regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014;14(3):141–153. doi:10.1038/nri3608
44. Neuhaus J, Jacobs DR Jr, Baker JV, Calmy A, Duprez D, La Rosa A, et al. Markers of inflammation, coagulation, and renal function are elevated in adults with HIV infection. J Infect Dis. 2010;201(12):1788–1795. doi:10.1086/652749
45. González-Hernández LA, Jave-Suarez LF, Fafutis-Morris M, Montes-Salcedo KE, Valle-Gutierrez LG, Campos-Loza AE, et al. Synbiotic therapy decreases microbial translocation and inflammation and improves immunological status in HIV-infected patients: A double-blind randomized controlled pilot trial. Nutr J. 2012;11:90. doi:10.1186/1475-2891-11-90
46. Mudd JC, Brenchley JM. Gut mucosal barrier dysfunction, microbial dysbiosis, and their role in HIV-1 disease progression. J Infect Dis. 2016;214(Suppl 2):S58–S66. doi:10.1093/infdis/jiw258
47. Lozupone CA, Li M, Campbell TB, Flores SC, Linderman D, Gebert MJ, et al. Alterations in the gut microbiota associated with HIV-1 infection. Cell Host Microbe. 2013;14(3):329–339. doi:10.1016/j.chom.2013.08.006
48. Tuychiev L.N., Raxmatullaeva Sh.B., Mamatmusaeva F.Sh., Saidova B.S. Kasallikning bosqichiga va immunitet holatiga qarab OIV bilan kasallangan bemorlarda ichak mikrobiotasining xususiyatlari Toshkent tibbiyot akademiyasi Urganch filiali janubiy orolbo`yi tibbiyot jurnali 1-Tom, 3-Son. 2025 ISSN: 3093-8740 146-152
49. Tuychiyev L.N., Mamatmusayeva F.SH, Saidova B.S., Murodova I.A. OIV-infeksiyali bemorlarda ichak mikrobiota o`zgarishlarining bakteriologik ko`rsatkichlari. O’zbekiston Harbiy Tibbiyoti 2025 4-son 216-220
50. Tuychiev L.N., Raxmatullaeva Sh.B., Nasirova X.P., Saidova B.S. Изменения флоры кишечника в зависимости от стадии ВИЧ инфекции, вирусной нагрузки и количества СD4 клеток. ВИЧ-инфекция и иммуносупрессии, 2026 г., Том 18, № 1 ISSN: 2077-9828 37-43
51. Lynch S.V., Pedersen O. Inson ichak mikrobiomi sog’liq va kasallikda. New England Journal of Medicine. 2016; 375(24): 2369–2379.
52. O’Callaghan A., van Sinderen D. Bifidobakteriyalar va ularning ichak mikrobiotasidagi roli. Frontiers in Microbiology. 2016, 7: 925.
53. Winter B.Y. Ichak o’tkazuvchanligini regulyatsiyasi. World Journal of Gastroenterology. 2017; 23: 2106.
