ISHEMIK INSULTDA MIYA TO‘QIMASI MORFOLOGIYASI: GIPERTONIYA VA ATEROSKLEROZ BILAN BOG‘LIQ JIHATLAR
Keywords:
serebrovaskulyar kasalliklar, ateroskleroz, arterial gipertoniya, ishemik insult, morfologiyaAbstract
Ishemik insultlarning asosiy morfologik substratini miya to‘qimasidagi distrofik, nekrobiotik va nekrotik o‘zgarishlar tashkil etadi. Ko‘pchilik ishemik zonalar tomir ishemiyasi, stenoz, angioskleroz hamda miya to‘qimasida gliyoz o‘choqlari mavjudligi bilan tavsiflanadi. Ushbu o‘zgarishlarning yoshga bog‘liq jihatlari asosan arterial gipertoniya va ateroskleroz bilan bog‘liq bo‘lib, ular tomir lümenining torayishiga, tomir devorida gialinoz o‘choqlari hosil bo‘lishiga, miya to‘qimasining plazmatik shimilishiga va bosh miya shishiga olib keladi. Jahon sog‘liqni saqlash tashkiloti (JSST) tasnifiga ko‘ra, ushbu patologik o‘zgarishlar ko‘pincha 45–59 yoshdagi shaxslarda uchraydi.
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References
1. Feigin V.L., Brainin M., Norrving B. et al. Global burden of stroke and risk factors in 1990–2019. The Lancet Neurology, 2021; 20(10): 795–820.
2. Campbell B.C.V., De Silva D.A., Macleod M.R. et al. Ischaemic stroke. Nature Reviews Disease Primers, 2019; 5(1): 70.
3. Iadecola C., Buckwalter M.S., Anrather J. Immune responses to stroke. Nature Reviews Neuroscience, 2020; 21(5): 263–280.
4. Dirnagl U., Iadecola C., Moskowitz M.A. Pathobiology of ischaemic stroke: an integrated view. Trends in Neurosciences, 2019; 42(10): 707–725.
5. Wardlaw J.M., Smith C., Dichgans M. Small vessel disease: mechanisms and clinical implications. The Lancet Neurology, 2019; 18(7): 684–696.
6. Seshadri S., Wolf P.A. Lifetime risk of stroke and dementia. Neurology, 2018; 91(10): e1023–e1031.
7. Jokinen H., Melkas S., Ylikoski R. et al. Post-stroke cognitive impairment. Stroke, 2020; 51(3): 698–705.
8. Liu Z., Chopp M., Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke. Progress in Neurobiology, 2016; 144: 103–120.
9. Burda J.E., Bernstein A.M., Sofroniew M.V. Astrocyte roles in ischemic brain injury. Nature Reviews Neuroscience, 2016; 17(10): 647–661.
10. Liddelow S.A., Barres B.A. Reactive astrocytes: production, function, and therapeutic potential. Immunity, 2017; 46(6): 957–967.
11. Moskowitz M.A., Lo E.H., Iadecola C. The science of stroke: mechanisms in search of treatments. Neuron, 2017; 67(2): 181–198.
12. Ospel J.M., Goyal M. Endovascular therapy for acute ischemic stroke. The Lancet, 2020; 396(10262): 1763–1774.
13. Khoshnam S.E., Winlow W., Farbood Y. et al. Pathogenic mechanisms following ischemic stroke. Neurological Sciences, 2017; 38(7): 1167–1186.
14. Zhang J., Yang Y., Sun H., Xing Y. Hemorrhagic transformation after cerebral infarction. Frontiers in Neurology, 2020; 11: 703.
15. Thiebaut de Schotten M., Foulon C., Nachev P. Brain disconnections in stroke. Nature Reviews Neurology, 2020; 16(5): 255–272.



















